Blar i forfatter "Fredriksen, Børge Nilsen"

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    • Antigen dose and humoral immune response correspond with protection for inactivated infectious pancreatic necrosis virus vaccines in Atlantic salmon (Salmo salar L) 

      Munang'andu, Hetron Mweemba; Fredriksen, Børge Nilsen; Mutoloki, Stephen; Dalmo, Roy Ambli; Evensen, Øystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      An enduring challenge in the vaccinology of infectious pancreatic necrosis virus (IPNV) is the lack of correlation between neutralizing antibodies and protection against mortality. To better understand the immunological basis of vaccine protection, an efficacy trial including Atlantic salmon (Salmo salar L.) vaccinated with a high antigen (HiAg) or low antigen (LoAg) dose vaccine was carried out ...

    • Differences in smolt status affect the resistance of Atlantic salmon (Salmo salar L.) against infectious pancreatic necrosis, while vaccine-mediated protection is unaffected 

      Jensen, Ingvill; Overrein, Mathias; Fredriksen, Børge Nilsen; Strandskog, Guro; Seternes, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-18)
      In today's aquaculture of Atlantic salmon (<i>Salmo salar</i> L.), a majority of viral disease outbreaks occur after seawater transfer. A relevant question is how the parr–smolt transformation influences the efficacy of viral vaccines and the innate resistance against viral diseases. In this study, vaccinated and unvaccinated A. salmon parr were exposed to different photoperiodic regimens (1‐, 3‐ ...

    • Fish Health Management in Uganda. From Soft Laws to Practical Implementation 

      Fredriksen, Børge Nilsen (Master thesis; Mastergradsoppgave, 2018-05-25)
      Fish farming is becoming an increasingly important part of the food supply for the growing world population. Uganda is one of the countries in Africa where fish farming is on the rise, largely dominated by Nile tilapia and North Africa Catfish. With abundant water resources, an ideal climate and a market demand for fish, the conditions for development of the fish farming sector are in place. In this ...

    • IPNV with high and low virulence: host immune responses and viral mutations during infection 

      Skjesol, Astrid; SkjÆveland, ingrid; Elnæs, Marianne; Timmerhaus, Gerrit Frantz; Fredriksen, Børge Nilsen; Jørgensen, Sven Martin; Krasnov, Aleksei; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Infectious pancreatic necrosis virus (IPNV) is an aquatic member of the Birnaviridae family that causes widespread disease in salmonids. IPNV is represented by multiple strains with markedly different virulence. Comparison of isolates reveals hyper variable regions (HVR), which are presumably associated with pathogenicity. However little is known about the rates and modes of sequence divergence and ...

    • Mapping uncertainties in the upstream : the case of PLGA Nanoparticles in Salmon Vaccines. 

      Nielsen, Kåre Nolde; Fredriksen, Børge Nilsen; Myhr, Anne Ingeborg (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The diversity of nanotechnologies and of the governance challenges that their applications raise calls for exploration and learning across different cases. We present an Upstream Oversight Assessment (UOA) of expected benefits and potential harms of nanoparticles made of a synthetic polymer (PLGA) to improve vaccines for farmed salmon. Suggested by Jennifer Kuzma and colleagues, an UOA may help ...

    • PLGA and PLA particles as vaccine delivery systems for Atlantic salmon : a study on formulation and use with an emphasis on immune responses 

      Fredriksen, Børge Nilsen (Doctoral thesis; Doktorgradsavhandling, 2012-06-07)
      Vaccines are regarded as the safest and most cost-effective strategy to prevent infectious diseases. For some diseases, vaccine improvements are required as protection levels are still inadequate. The key to solving this challenge might lie in the development of more efficacious vaccine delivery systems and adjuvants. Poly (lactide-co-glycolide) (PLGA) is a biodegradable polymer which has an extensive ...

    • Transgene and immune gene expression following intramuscular injection of Atlantic salmon (Salmo salar L.) with DNA-releasing PLGA nano- and microparticles 

      Hølvold, Linn Benjaminsen; Fredriksen, Børge Nilsen; Bøgwald, Jarl; Dalmo, Roy Ambli (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The use of poly-(D,L-lactic-co-glycolic) acid (PLGA) particles as carriers for DNA delivery has received considerable attention in mammalian studies. DNA vaccination of fish has been shown to elicit durable transgene expression, but no reports exist on intramuscular administration of PLGA-encapsulated plasmid DNA (pDNA). We injected Atlantic salmon (Salmo salar L.) intramuscularly with a plasmid ...